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작성일 2023-04-11 21:22:53
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※ PRR reporter cells | TLR reporter cells | ● : Colorimetric (620-655 nm) / ● : Luminescent | | CELL LINE | PRODUCT | PATHWAYS STUDIED / DESCRIPTION | DETECTION | CAT. CODE | | HEK293 (human) | HEK-Blue™ hTLR2 | Human TLR2 / NF-κB-reporter cells | ● | hkb-htlr2 | | HEK-Blue™ hTLR2-TLR1 | Human TLR2-TLR1/ NF-κB | ● | hkb-htlr21 | | HEK-Blue™ hTLR2-TLR6 | Human TLR2-TLR6 / NF-κB | ● | hkb-htlr26 | | HEK-Blue™ hTLR2 KO-TLR1/TLR6 | Human TLR2 / NF-κB, knockout of human TLR2 and TLR6 | ● | hkb-htlr2k16 | | HEK-Blue™ hTLR3 | Human TLR3 / NF-κB | ● | hkb-htlr3 | | HEK-Blue™ hTLR4 | Human TLR4-MD2-CD14 / NF-κB | ● | hkb-htlr4 | | HEK-Blue™ hTLR5 | Human TLR5 / NF-κB | ● | hkb-htlr5 | | HEK-Blue™ hTLR7 | Human TLR7 / NF-κB | ● | hkb-htlr7v2 | | HEK-Blue™ hTLR8 | Human TLR8 / NF-κB | ● | hkb-htlr8 | | HEK-Blue™ hTLR9 | Human TLR9 / NF-κB | ● | hkb-htlr9 | | HEK-Blue™ mTLR2 | Mouse TLR2 / NF-κB | ● | hkb-mtlr2 | | HEK-Blue™ mTLR3 | Mouse TLR3 / NF-κB | ● | hkb-mtlr3 | | HEK-Blue™ mTLR4 | Mouse TLR4-MD2-CD14 / NF-κB | ● | hkb-mtlr4 | | HEK-Blue™ mTLR5 | Mouse TLR5 / NF-κB | ● | hkb-mtlr5 | | HEK-Blue™ mTLR7 | Mouse TLR7 / NF-κB | ● | hkb-mtlr7 | | HEK-Blue™ mTLR8 | Mouse TLR8 / NF-κB | ● | hkb-mtlr8 | | HEK-Blue™ mTLR9 | Mouse TLR9 / NF-κB | ● | hkb-mtlr9 | | HEK-Blue™ mTLR13 | Mouse TLR13 / NF-κB | ● | hkb-mtlr13 | | HEK-Dual™ hTLR2 | Double readout (NF-κB / IL-8), human TLR2, Lucia knocked into IL-8 | ● / ● | hkd-htlr2ni | | HEK-Dual™ hTLR3 | Double readout (NF-κB / IL-8), human TLR3, Lucia knocked into IL-8 | ● / ● | hkd-htlr3ni | | HEK-Dual™ hTLR5 | Double readout (NF-κB / IL-8), human TLR5, Lucia knocked into IL-8 | ● / ● | hkd-htlr5ni | | HEK-Dual™ hTLR9 | Double readout (NF-κB / IL-8), human TLR9, Lucia knocked into IL-8 | ● / ● | hkd-htlr9ni | | HEK-Dual™ mTLR4 | Double readout (NF-κB / IL-8), mouse TLR4-MD2-CD14, Lucia knocked into IL-8 | ● / ● | hkd-mtlr4ni | | HEK-Dual™ mTLR7 | Double readout (NF-κB / IL-8), mouse TLR7, Lucia knocked into IL-8 | ● / ● | hkd-mtlr7ni | | THP-1 (human) | THP1-Dual™ KO-TLR2 | NF-κB & IRFs, knockout of human TLR2 | ● / ● | thpd-kotlr2 | | THP1-Dual™ KO-TLR4 | NF-κB & IRFs, knockout of human TLR4 | ● / ● | thpd-kotlr4 | | THP1-Dual™ KO-TLR8 | NF-κB & IRFs, knockout of human TLR8 | ● / ● | thpd-kotlr8 | | THP1-Dual™ hTLR9 | Human TLR9 / NF-κB & IRFs | ● / ● | thpd-htlr9 | | RAW (mouse) | RAW-Dual™ KO-TLR4 | Double readout (IRFs / MIP), knocked out for mouse TLR4 | ● / ● | rawd-kotlr4 |
| CLR reporter cells |
| | CELL LINE | PRODUCT | PATHWAYS STUDIED / DESCRIPTION | DETECTION | CAT. CODE | | HEK293 (human) | HEK-Blue™ hDectin-1a | Human Dectin-1a / NF-Κb | ● | hkb-hdect1a | | HEK-Blue™ hDectin-1b | Human Dectin-1b / NF-κB | ● | hkb-hdect1b | | HEK-Blue™ mDectin-1b | Mouse Dectin-1b / NF-κB | ● | hkb-mdect1b | | HEK-Blue™ mDectin-2 | Mouse Dectin-2 / NF-κB | ● | hkb-mdect2 | | HEK-Blue™ mMincle | Mouse Mincle / NF-κB | ● | hkb-mmcl |
| NOD reporter cells |
| | CELL LINE | PRODUCT | PATHWAYS STUDIED / DESCRIPTION | DETECTION | CAT. CODE | | HEK293 (human) | HEK-Blue™ hNOD1 | Human NOD1 / NF-κB | ● | hkb-hnod1 | | HEK-Blue™ hNOD2 | Human NOD2 / NF-κB | ● | hkb-hnod2 | | HEK-Blue™ mNOD1 | Mouse NOD1 / NF-κB | ● | hkb-mnod1 | | HEK-Blue™ mNOD2 | Mouse NOD2 / NF-κB | ● | hkb-mnod2 |
| RLR reporter cells | | CELL LINE | PRODUCT | PATHWAYS STUDIED / DESCRIPTION | DETECTION | CAT. CODE | | A549 (human) | A549-Dual™ KO-MDA5 | NF-κB & IRFs, knockout of human MDA-5 | ● / ● | a549d-komda5 | | A549-Dual™ KO-RIG-I | NF-κB & IRFs, knockout of human RIG-I | ● / ● | a549d-korigi | | A549-Dual™ KO-MAVS | NF-κB & IRFs, knockout of human MAVS | ● / ● | a549d-komavs | | RAW (mouse) | RAW-Lucia™ ISG-KO-MDA5 | IRFs, knockout of mouse MDA-5 | ● | rawl-komda5 | | RAW-Lucia™ ISG-KO-RIG-I | IRFs, knockout of mouse RIG-I | ● | rawl-korigi | | RAW-Lucia™ ISG-KO-MAVS | IRFs, knockout of mouse MAVS | ● | rawl-komavs | | HEK293 (human) | HEK-Lucia™ RIG-I | IRFs, overexpression of human RIG-I | ● | hkl-hrigi | | THP1 (human) | THP1-Dual KO MDA-5 | NF-κB & IRFs, knockout of human MDA-5 | ● / ● | thpd-komda5 | | THP1-Dual KO RIG-I | NF-κB & IRFs, knockout of human RIG-I | ● / ● | thpd-korigi | | THP1-Dual KO MAVS | NF-κB & IRFs, knockout of human MAVS | ● / ● | thpd-komavs |
| Cytosolic DNA sensor & STING reporter cells | | CELL LINE | PRODUCT | PATHWAYS STUDIED / DESCRIPTION | DETECTION | CAT. CODE | | B16 (mouse) | B16-Blue™ ISG-KO-STING | IRFs, knockout of mouse STING | ● | bb-kostg | | HEK293 (human) | HEK-Blue™ ISG-KO-STING | IRFs, knockout of human STING | ● | hkb-kostg | | 293-Dual™ hSTING-A162 | Double readout (IRFs & IFN-β), Lucia knocked into IFN-β, S162A human STING transfected | ● / ● | 293d-a162 | | 293-Dual™ hSTING-H232 | Double readout(IRFs & IFN-β), Lucia knocked into IFN-β, R71-G230-H232-R293 human STING transfected | ● / ● | 293d-h232 | | HEK-Blue STAT6-hSTING R232 | STAT6-specific SEAP expression | ● | hkb-st6r232 | | 293-Dual™ hSTING-R232 | Double readout (IRFs & IFN-β), Lucia knocked into IFN-β, R71-G230-R232-R293 human STING transfected | ● / ● | 293d-r232 | | 293-Dual™ mSTING | Double readout (IRFs & IFN-β), Lucia knocked into IFN-β, mouse STING transfected | ● / ● | 293d-mstg | | RAW (mouse) | RAW-Lucia™ ISG-KO-cGAS | IRFs, knockout of mouse cGAS | ● | rawl-kocgas | | RAW-Lucia™ ISG-KO-IFI16 | IRFs, knockout of mouse IFI16 Lucia rawl-koif16 | ● | rawl-koif16 | | RAW-Lucia™ ISG-KO-STING | IRFs, knockout of mouse STING | ● | rawl-kostg | | Raw-lucia ISG-KO-TREX1 | IRFs, knockout of mouse TREX1 | ● | rawl-kotrex | | THP-1 (human) | THP1-Dual™ KO-cGAS | NF-κB & IRFs, knockout of human cGAS | ● / ● | thpd-kocgas | | THP1-Dual™ KO-IFI16 | NF-κB & IRFs, knockout of human IFI16 | ● / ● | thpd-koifi16 | | THP1-Dual™ KO-STING | NF-κB & IRFs, knockout of human STING | ● / ● | thpd-kostg | | THP1-Dual™ KI-hSTING-A162 | NF-κB & IRFs, knockin of S162A human STING (DMXAA sensitive isoform) | ● / ● | thpd-a162 | | THP1-Dual™ KI-hSTING-H232 | NF-κB & IRFs, knockin of R71-G230-H232-R293 human STING | ● / ● | thpd-h232 | | THP1-Dual™ KI-hSTING-M155 | NF-κB & IRFs, knockin of V155M human STING (constitutively active isoform) | ● / ● | thpd-m155 | | THP1-Dual™ KI-hSTING-R232 | NF-κB & IRFs, knockin of R71-G230-R232-R293 “wild-type” human STING | ● / ● | thpd-r232 | | THP1-Dual™ KI-hSTING-S154 | NF-κB & IRFs, knockin of N154S human STING (constitutively active isoform) | ● / ● | thpd-s154 | | THP1-Dual™ KI-mSTING | NF-κB & IRFs, knockin of mouse STING | ● / ● | thpd-mstg | | THP1-Dual™ KO-TREX1 | NF-κB & IRFs, knockin of human TREX1 | ● / ● | thpd-kotrex |
| ALPK1/TIFA | | CELL LINE | PRODUCT | PATHWAYS STUDIED / DESCRIPTION | DETECTION | CAT. CODE | | HEK293 (human) | HEK-Blue™ KO-ALPK1 | Knockout (KO) of the ALPK1 gene | ● | hkb-koalpk | | HEK-Blue™ KO-TIFA | Knockout (KO) of the TIFA gene | ● | hkb-kotifa |
※ TRANSCRIPTION FACTOR reporter cells | Transcription factor reporter cells (Human) | ● : Colorimetric (620-655 nm) / ● : Luminescent | | CELL LINE | PRODUCT | PATHWAYS STUDIED / DESCRIPTION | DETECTION | CAT. CODE | | A549 (human) | A549-Dual™ | NF-κB & IRFs | ● / ● | a549d-nfis | | HCT116 (human) | HCT116-Dual™ | NF-κB & IRFs | ● / ● | hctd-nfis | | HEK293 (human) | HEK-Blue™ ISG | IRFs | ● | hkb-isg | | 293-Dual™ Null | Double readout (IRFs/ IFN-β), Lucia knocked into IFN-β | ● / ● | 293d-null | | HEK-Dual™ Null | Double readout (NF-κB / IL-8), Lucia knocked into IL-8 | ● / ● | hkd-nullni | | HepG2 (human) | HepG2-Dual™ | NF-κB & IRFs | ● / ● | hepg2d-nfis | | HepG2-Lucia™ AhR | AhR | ● | hpgl-ahr | | HT29 (human) | HT29-Lucia™ | AhR | ● | ht2l-ahr | | Jurkat (human) | Jurkat-Dual™ | NF-κB & IRFs | ● / ● | jktd-isnf | | Jurkat-Lucia™ NFAT | NFAT | ● | jktl-nfat | | Jurkat-Lucia™ NFAT-CD16 | NFAT, human CD16A (FcγRIIIA, V158 allotype) transfected | ● | jktl-nfat-cd16 | | Ramos (human) | Ramos-Blue™ | NF-κB / AP-1 | ● | rms-sp | | Ramos-Blue™ KD-MyD | NF-κB / AP-1, knockdown of human MyD88 | ● | rms-kdmyd | | THP-1 (human) | THP1-Blue™ | NF-κB NF-κB | ● | thp-nfkb |
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